Infiltration of CD45RO~+ T cells and CD68~+ cells in non-neoplastic epithelial disorders and vulva cancer
- VernacularTitle:CD45RO~+T细胞和CD68~+细胞在外阴上皮内非瘤样病变和外阴癌中的侵润
- Author:
Datong TIAN
;
Xin WU
- Publication Type:Journal Article
- Keywords:
Non-neoplastic epithelial disorders of the vulva;
Valvar cancer;
CD45RO~+ T cell;
CD68~+ cell
- From:
Chinese Journal of Immunology
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the infiltration of CD45RO+ T cells and CD68+ cells in the lesions of non-neoplastic epithelial disorder and in vulva cancer.Methods:The infiltration of CD45RO+ T cells and CD68+ cells was detected with S-P immunohistochemistry in the lesions of 20 non-neoplastic epithelial disorders,including vulvar squamous cell hyperplasia(SH) and vulvar lichen sclerosus(LS)) and vulvar cancer,respectively.The vulvar skins from 10 healthy individuals were selected as the control.Results:The infiltration of CD45RO+ T cells and CD68+ cells in healthy vulvar skin was very low and significantly lower than that in SH,LS and vulvar cancer(P0.05).The number of both cells were significantly higher than that in SH,poorly vulvar cancer and early stage of LS(P0.05).The infiltration of CD68+ cells was shown in a positive correlation with CD45RO+ T cells in the different lesion of vulva,the correlation coefficient was 0.742(P
