Effect of Butylbenzyl Phthalate(BBP) on Levels of DNA-protein Crosslinks in Hepatic Cells of Mice
- VernacularTitle:邻苯二甲酸丁基苄酯对小鼠肝脏DNA-蛋白质交联水平的影响
- Author:
Jing GUO
;
Chenxi WEI
;
Dandan LIU
- Publication Type:Journal Article
- Keywords:
Butylbenzyl phthalate;
DNA-protein crosslinks;
DNA damage
- From:
Journal of Environment and Health
2007;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the effect of butylbenzyl phthalate(BBP) on the levels of DNA-protein crosslinks(DPC) in hepatic cells of mice.Methods Twenty-five male Kunming mice were randomly assigned into five groups(n=5).BBP was administered by intraperitoneal injection at doses of 0(control group),125,250,500,1 000 mg/kg respectively for 14 consecutive days.Then the levels of DNA-protein crosslinks were detected.Results DPC coefficient increased with concentration of BBP increasing.Treatments of 500 and 1 000 mg/kg BBP significantly increased the levels of DPC compared with the control group. Conclusion BBP can not cause DPC at low levels(125 mg/kg),but it can cause DPC significantly at high levels(500 and 1000 mg/kg),which may cause serious DNA damages.
