Relationship between AQP4 mRNA expression in bronchial epithelium of patients with COPD and the airway inflammation
- VernacularTitle:慢性阻塞性肺病中AQP4 mRNA的表达变化及与气道炎症的相关研究
- Author:
Bo ZHU
;
Lan YANG
;
Tianjun CHEN
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary disease;
aquaporin;
airway inflammation
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect and significance of AQP4 mRNA expression in bronchial epithelium of chronic obstructive pulmonary disease (COPD) on airway inflammation. Methods Bronchial epithelium was obtained by bronchoscopy in patients with COPD (n=30) and healthy controls (n=30) whose bronchial epithelium was confirmed to be normal by the pathologist. AQP4 mRNA were studied by RT-PCR method. Inflammatory cells infiltration was observed by HE staining; pulmonary function test was performed too before bronchoscopy. Results Compared with that in the healthy controls, AQP4 mRNA expression in COPD was reduced (P
