Antisense intergrin ?V and integrin ?3 suppresses the growth of pancreatic carcinoma in rats
- VernacularTitle:整合素?V和?3反义基因抑制大鼠胰腺癌生长的实验研究
- Author:
Xu HAN
;
Jie LI
;
Changwen SHI
;
Jie LI
;
Zongzhen XU
;
Jingjie SUN
- Publication Type:Journal Article
- Keywords:
Integrins?Pancreatic neoplasms?Cell apoptosis?Gene therapy?Angiogenesis
- From:
Chinese Journal of Current Advances in General Surgery
2004;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate antisense integrin?V and ?3 gene therapy in Rats mod- el of Pancreatic Carcinoma. Methods: The antisense integrin?V and ?3 expression plasmids wereelectrobloted into pancreatic tumours of rats induced by dimethylbenzanthracine,The tumor inhibit rate was calculated, the tumor microvessel density(MVD)with the immunohistochemical staining and tumor apoptosis with TUNEL were examined. Results: The tumor weight of the control group, ?V group, ?3 group an- d?V?3 group was (1.167?0.79)g(,0.953?0.26)g(,1.013?0.42)g(,0.788?0.56)g respectively. The dif- ference was significant among them(P
