Expression of BUB1 and APC protein in different breast tissues and its clinical signifi cance
- VernacularTitle:BUB1与APC蛋白在不同乳腺组织中的表达及临床意义
- Author:
Yahong WANG
;
Xinghua SUN
;
Zhitu ZHU
;
Minwen HA
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
metastasis;
immunohistochemistry
- From:
China Oncology
2006;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:The development of breast cancer is a multi-step process associated with changes in host chromosome,and some of which correlate with the appearance and progression of the tumor. We studied the expression of BUBl,APC protein in normal breast,hyperplasia of mammary glands and breast cancer tissues and evaluated its difference and clinical significance. Methods:The inmmunohistochemical method was used to analyze the expression of BUB1 and APC protein in normal breast,hyperplasia of mammary glands and breast cancer tissues. Results:The positive rate of BUB1 protein expression in normal,hyperplasia of mammary glands and breast cancer tissues was 86.7%,80.0% and46.0%,respectively.There were signifi cant differences among the three breast tissues(P
