Study of Mechanism of Preoperative Oral Carbohydrate Involved in Attenuating Postoperative Insulin Resistance
- VernacularTitle:术前口服碳水化合物改善术后胰岛素抵抗的作用及其机理研究
- Author:
Zhiguo WANG
;
Zhe YANG
;
Huanlong QIN
- Publication Type:Journal Article
- Keywords:
Colorectal surgery Carbohydrate Insulin resistance Mechanism
- From:
Chinese Journal of Bases and Clinics in General Surgery
2008;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the tolerance of preoperative carbohydrate-rich beverage,to determine its effect on postoperative insulin resistance and analyze its potential mechanism.Methods Thirty-two patients undergoing elective colorectal cancer resection were recruited to this randomized controlled study and assigned to two groups at random.Patient in control group was fasted before operation,while patient in study group was given oral water.Homeostasis model assessment(HOMA)indexes,activity of PTK,and mRNA and(or)protein expressions of PKB,PI3K and GluT4 were measured before and(or)immediately after surgery.Furthermore preoperative well-beings of patients were studied.Results Among well-beings,feeling of thirst,hunger and anxiety tended to be better in patients receiving carbohydrate-rich beverages compared with fasted ones(P0.05).Conclusion Preoperative consumption of carbohydrate-containing fluids is safe and effective.Provision of carbohydrate energy source prior to surgery may attenuate immediate postoperative insulin resistance.A carbohydrate-rich drink enhances insulin action at the time of onset of anaesthesia or surgery by activating three kinases named PTK,PI3K,PKB which are key enzymes in pathway of insulin signal transduction.It is likely to explain the effects on postoperative insulin resistance.
