Expression of Suppressor Gene Runt-Related Transcription Factor 3 in Gastric Carcinoma and Its Relationship with Clinical Pathological Parameters
- VernacularTitle:抑癌基因Runt相关转录因子3在胃癌中的表达及其与临床病理学因素的关系
- Author:
Jianhai ZHANG
;
Liyi LI
;
Jikun LI
- Publication Type:Journal Article
- Keywords:
Runt-related transcription factor 3 Stomach neoplasm Suppressor gene Pathology
- From:
Chinese Journal of Bases and Clinics in General Surgery
2008;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of suppressor gene Runt-related transcription factor 3(Runx3)in gastric carcinoma and its relationship with clinicopathologic parameters.Methods RT-PCR and Western blot were used to determine the mRNA expression and protein expression of Runx3 gene in primary tumor and corresponding normal tissues respectively in 52 patients with gastric carcinoma.The relationship between Runx3 expression and clinicopathologic parameters was analyzed.Results RT-PCR and Western blot analysis in 52 patients with gastric carcinoma showed down-regulation of Runx3 mRNA and Runx3 protein in 59.6%(31/52)and 48.1%(25/52)of the primary tumors tested,and in none of the normal tissues(P
