Effect of Probiotics on The Change of Intestinal Barrier Function and Inflammatory Response after Surgery of Colorectal Cancer
- VernacularTitle:益生菌对大肠癌术后肠屏障功能及全身炎症反应的影响
- Author:
Yang XIA
;
Huanlong QIN
- Publication Type:Journal Article
- Keywords:
Probiotics Intestinal permeability Intestinal barrier function Colorectal cancer
- From:
Chinese Journal of Bases and Clinics in General Surgery
2008;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of probiotics on the change of intestinal permeability and inflammatory reaction after surgery of colorectal cancer.Methods Sixty patients who underwent colonic surgery were randomly divided into two groups:probiotic group and control group,with 30 cases in each group.Each group received nutritional support of the same nitrogen and calorie from day 3 to day 7 after operation.The patients in probiotic group were orally administrated probiotic(2 g/d)from the first day after surgery for 7 days.Every patient's body temperature and heart rate were observed after operation,and white blood cell counts were observed before operation and on day 1,5,8 after operation.The levels of microbial DNA in whole blood and plasma D-lactate,and urine lactulose/mannito(L/M)ratio were measured before operation and on day 1 and day 8 after operation,respectively.In addition,the occurrence of postoperative systemic inflammatory response syndrome(SIRS)and complications of inflammation were closely observed.Results The average heart rate in postoperative 5 days was significantly lower in probiotics group than that in control group(P0.05).Conclusion Probiotics can decrease intestinal permeability and maintain the intestinal barrier function after operation.It may be helpful for the recovery of patients with early inflammatory response after surgery of colorectal cancer.
