Human Embryo Liver L-02 Cells Damage Induced by Fullerene
- VernacularTitle:富勒烯对人胚肝细胞L-02的损伤作用
- Author:
Jingshu ZHANG
;
Shanshan BAI
;
Shanshan QIAO
- Publication Type:Journal Article
- Keywords:
Fullerene;
L-02 cells;
Cytotoxicity;
Oxidative damage
- From:
Journal of Environment and Health
2007;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the toxicity and mechanism of fullerene(C_(60))on human embryo liver L-02 cells.Methods L-02 cells were exposed to C_(60)suspension of different concentrations(0.00,1.25,2.50,5.00,10.00,20.00 and 40.00?g/ml)for 24 h,then the content of GSH and the activity of LDH,SOD were determined,the viability of cells with/without NAC was also compared.Results Compared to the control group,the viability of cells exposed to 1.25,2.50,5.00,10.00,20.00 and 40.00?g/ml C_(60)suspension decreased in a dose-dependent manner,and the differences were significant(P
