The analysis of HLA-DRB1 allelic polymorphism in Tu race population of Qinghai region of China
- VernacularTitle:青海土族人群HLA-DRB1等位基因多态性分析
- Author:
Haixia CAO
;
Xin XU
;
Jun HONG
;
Jing WANG
- Publication Type:Journal Article
- Keywords:
Qinghai Tuzhu;
Human leukocyte antigen;
HLA-DRB1;
Polymorph
- From:
Chinese Journal of Immunology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the HLA-DRB1 allele polymorphism of the Tu race population in Qinghai region of China.Methods:Polymerase chain reaction and hybridizations of sequence-specific olignucleotide probe was used to detect HLA-DRB1 alleles in 50 unrelated healthy Tu individuals from Qinghai region,and the results were compared with those of minority populations in China.Results:Sixteen of alleles were detected and identified for HLA-DRB.HLA-DRB11*04,DRB1*08,DRB1*14,DRB1*15,DRB3*,DRB4* were the most common alleles.The frequency of DRB1*06,DRB1*07,DRB1*09,DRB1*13,DRB1*16,DRB1*23 were lower.Conclusion:The allelic polymorphism of HLA loci of Tu race population in Qinghai area has its own characteristics.
