The overexpression of ULBP2 in the brain of drug-refractory epilepsy
- VernacularTitle:耐药性颞叶癫痫脑组织中UL16结合蛋白2(ULBP2蛋白)的表达及临床意义
- Author:
Lifeng GUAN
;
Xuefeng WANG
;
Tao LIN
;
Yan ZENG
;
Jinmei LI
;
Fei XIAO
;
Jijun SUN
;
Xi ZHU
;
Hui YANG
;
Guoming LUAN
;
Yuping WANG
;
Yong LU
;
Hongwei LI
- Publication Type:Journal Article
- Keywords:
ULBP2 protein;
Epilepsy;
Immune reaction;
Temporal lobe
- From:
Chinese Journal of Immunology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of ULBP2 protein in the brain tissues of patients with drug-refractory epilepsy and its clinical significance.Methods:Gene-chip,immunofluorescence and Western blot were used to test expression of ULBP2 in the surgically removed brain tissue of patients with drug-refractory epilepsy from the brain bank of our department(n=42),and the results were compared with that of normal controls (n=12).Results:The relative increasing expression of ULBP2-gene in the brain of patients with drug-refractory epilepsy,and ULBP2 protein expression was significantly increased in temporal lobe cortex of patients with drug-refractory epilepsy as compared with the same regions of the controls specimens.Conclusion:The results indicate that the overexpression of ULBP2 may be involved in the pathophysiology of drug-refractory epilepsy.
