Effects of Different Stresses on Hippocampal Monoamine Level in Rat Under Simulated High-altitude Hypobaric Hypoxia
- VernacularTitle:不同应激方式对模拟高原环境下大鼠海马单胺递质的影响
- Author:
Wentao MA
;
Zihe DENG
;
Laiqi YANG
- Publication Type:Journal Article
- Keywords:
Stress;
Hypoxia;
Hippocampus;
Push-pull perfusion;
Monoamine
- From:Chinese Journal of Clinical Psychology
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the effects of psychological and physiological stress on hippocampal extracellular monoamine content under simulated high-altitude hypobaric hypoxia.Methods:The male SD rats were randomly divided into ten groups:control(Con group), hypoxia(Hy group), psychological stress(twice/day)(Ps1group), psychological stress(twice/day?2day)(Ps2 group), psychological stress(twice/day) + hypoxia(Ps1+Hy group), psychological stress(twice/day? 2day) +hypoxia(Ps2+Hy group), physiological stress(twice/day)(Ph1group), physiological stress(twice/day?2day)(Ph2 group), physiological stress(twice/day) + hypoxia(Ph1+Hy group), physiological stress(twice/day?2day) + hypoxia(Ph2+Hy group).The contents of norepinephrine(NE), dopamine(DA) and 5-hydroxytryptamine(5-HT) in extracellular fluid of hippocampus collected by push-pull perfusion were determined by high performance liquid chromatography with electrichemical detection(HPLC-ECD).Results:①Compared with the Con group, the content of NE was significantly lower in Hy, Ps1+Hy and Ph2+Hy groups(P
