CHANGE OF LIPOPEROXIDE AND ITS INFLUENCE ON PULMONARY SURFACTANT IN SCALDED RATS
- VernacularTitle:大鼠烫伤后脂质过氧化物变化及其对肺表面活性物质的影响
- Author:
Zhiqiang HU
- Publication Type:Journal Article
- Keywords:
pulmonary surfactant;
film balance;
lipid peroxide;
scalding;
rats
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
In the present study we measured the lipid peroxide content in plasma and lung homogenate by Yagi's method, and analyzed the composition of surfactant phospholipid and surface activity of pulmonary surfactant by thin layer chrom-otography and by Wilhelmy's film balance.The results showed that the lipid peroxide level was increased in plasma and lung homogenate; licithine,tysopho-spholipidcholine and phosphatidylethanolamine were decreased in bronchial-alveolar lavege fluid; and pulmonary surfactant surface activity was lowered.The findings suggest that decreased surface activity may result from the decrease of disaturated phospholipidcholine, which may be due to its impaired synthesis.
