Advances in research on the mechanisms of trastuzumab resistance and strategies to overcome the resistance
- VernacularTitle:曲妥珠单抗耐药的机制和对策研究进展
- Author:
Yuqian LIAO
;
Binghe XU
- Publication Type:Journal Article
- Keywords:
breast cancer;
trastuzumab;
drug resistance
- From:China Oncology
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Trastuzumab is one of the most important drugs for HER2 overexpressing breast cancer patients. However, even for these patients, the objective response rates to trastuzumab monotherapy are 12%-34%, and the median duration is about 9 months. Many patients progress within 12 months. Study of the mechanisms of resistance to trastuzumab will help us fi nd some new drugs and methods to overcome or delay the resistance.
