Advance in the study of ?1,3 fucosyltransferase Ⅶ and glycoprotein CD24 in tumor metastasis
- VernacularTitle:?1,3岩藻糖基转移酶Ⅶ和糖蛋白CD24与肿瘤转移的研究进展
- Author:
Wenhua LI
;
Wen ZHANG
- Publication Type:Journal Article
- Keywords:
FucT-Ⅶ;
CD24;
fucosylation;
tumor metastasis
- From:
China Oncology
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Tumor recurrence and metastasis are the major cause for cancer patient death. Aberrant glycosylation is one of the important mechanisms of malignant tumor metastasis. The glycoprotein CD24, which could be a ligand for P-selectin on the surface of activated endothelial cells and platelets, appears to be a new diagnostic marker of tumors and possibly participates in tumor metastasis with unknown pathway. ?1,3 Fucosyltransferase Ⅶ (FucT-Ⅶ) is one of the fucosyltransferases which catalyze the transfer of a fucosyl residue from GDP-?-L-fucose to a sugar acceptor, usually galactose in the sugar chains of glycoproteins or glycolipids. The elevated expression of sialyl Lewis (SLeX), the only carbohydrate product of ?1,3 FucT-Ⅶ , predicts an ominous prognosis and high risk of recurrence and regulates the function of CD24. It is possible that ?1,3 FucT-Ⅶ may enhance the glycosylation of CD24 and thus promote the tumor metastasis.
