Expressions of leptin,COX-2 and p27 in bile-induced gastric mucosa injury
- VernacularTitle:胆汁致胃黏膜损伤中瘦素、环氧合酶-2及p27的表达
- Author:
Yinxue SONG
;
Jun GONG
- Publication Type:Journal Article
- Keywords:
bile;
gastric mucosal;
leptin;
COX-2;
p27
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of leptin,COX-2 and p27 in bile-induced gastric mucosal injury in rats.Methods SD rats were divided into 4 groups: DGR(duodenogastric reflux) group,DGR+BDL(ligation of bile duct) group,BDL group and control group.The pathological changes of gastric mucosa and tight junction were observed,DIXON scores were warked out after 3 months.Immunohistochemistry was used to detect the expression of leptin,COX-2 and p27 in gastric mucosa with different lesions. Results The DIXON scores in DGR and DGR+BDL group were higher than those in BDL group and control group(P
