WWOX gene expression in non-small cell lung cancer and its clinical significance
- VernacularTitle:WWOX蛋白在非小细胞肺癌中的表达及其临床意义
- Author:
Qiufang LI
;
Ruiling YANG
;
Jing WANG
;
Yimin WU
- Publication Type:Journal Article
- Keywords:
non-small cell lung cancer(NSCLC);
WWOX gene;
WWOX protein
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of WWOX gene in non-small cell lung cancer and its significance. Methods WWOX protein expression was evaluated by immunohistochemistry in 81 NSCLC patients(50 squamous cell carcinomas,31 adenocarcinomas and 20 adjacent normal lung tissues),and correlation with histopathologic(histotype,grade,tumor-node-metastasis,stage) and clinical characteristics was studied. Results WWOX expression was absent/reduced in 72.8% of NSCLC,whereas it was normal in 80.0% of adjacent normal lung tissues.WWOX expression was strongly associated with tumor histology and histologic grade(P
