Preparation of metformin hydrochloride pellets with centrifugal granulation technique
- VernacularTitle:应用离心造粒法制备盐酸二甲双胍微丸的研究
- Author:
Xiaoming LI
;
Xiumei TAO
;
Xiaoli WANG
;
Jicheng LIU
- Publication Type:Journal Article
- Keywords:
pellets;
centrifugal granulation;
metformin hydrochloride;
structure construction of cage
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare metformin hydrochloride pellets with centrifugal granulator by powder layering technique. Methods Metformin hydrochloride and MCC pellets were prepared by means of powder layering with the centrifugal granulation equipment and evaluated by yield percentage,angle of repose,bulk density,and friability. Results The preparation process parameters were optimized as follows: the ratio of metformin hydrochloride and lactose and MCC was 100∶5∶3,150 r/min rotating speed of the centrifugal granulation,20 r/min spraying serosity speed,25 r/min purveying powder speed,and the time of spheronization was 6 min.Metformin hydrochlorid pellets were prepared under the condition. Conclution The metformin hydrochloride pellets had good appearance,uniform granulation diameter,standard rigidity,good fluidity and did not have the structure of cage by means of detecting dissolubility.
