Correlation between sensitiviy of neoadjuvant chemotherapy and multidrug-resistance in breast carcinoma
- VernacularTitle:乳腺癌组织多药耐药相关蛋白表达及其与化疗敏感性关系的研究
- Author:
Yong SUN
;
Kai YUAN
- Publication Type:Journal Article
- Keywords:
Multidrug resistance-associated proteins?Immunohistochemistry? Breast carcinoma
- From:
Chinese Journal of Current Advances in General Surgery
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expressions of P-gp、GST-?、TopoⅡin breast carcinoma and the relationship between the drug resistance-associated proteins and the sensitivity of neoadjuvant chemotherapy of breast carcinoma.Methods:Eighty specimens of breast carcinoma were collected and the patients were classified randomly into group A and group B.Neoadjuvant chemotherapy(CEF)was used in group A,and we respectively measured maximum diameters of the tumors by B-ultrasound examination before and after the chemotherapy.we measured the expression of P-gp、GST-?、TopoⅡin 80 specimens by immunohistochemical technique(S-P).Results:The expression of P-gp increased significantly in group A compared with group B(P
