Suppressive effects of SIN on immunological function and cytokine production by T cells from the patients with SLE
- VernacularTitle:青藤碱对红斑狼疮患者外周血T细胞的抑制作用及机制探讨
- Author:
Yunzhen SHI
;
Rui MENG
;
Li LI
;
Changyou WU
- Publication Type:Journal Article
- Keywords:
SIN;
SLE;
T lymphocyte;
Cytokine
- From:
Chinese Journal of Immunology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of sinomenine(SIN)on the activation and function of T-cells from SLE patients and to elucidate the mechanisms for the immunosuppressive effect of SIN.Methods:PBMCs were isolated from SLE patients and stimulated with anti-CD3 in the presence or absence of different concentrations of SIN.The cytokines were measured by ELISIA,and the activation and function of T-cells were analyzed by flow cytometry.Results:SIN could inhibit IFN-?,IL-2 and IL-4 production of T cells in SLE patients' peripheral blood.In addition,SIN could significantly inhibit the expression of activation molecules CD69 and CD25 by CD4+ and CD8+ T cells.Conclusion:SIN could inhibit immune responses of SLE patients by suppressing T cells activation and cytokine secretion.
