An association of the HLA-DR and DQ polymorphisms with EHF in Han Nationality at Zunyi area
- VernacularTitle:HLA-DR、DQ基因多态性与遵义地区汉族流行性出血热相关性的研究
- Author:
Junmin LUO
;
Wanbang SUN
;
Xuegui HUANG
;
Jihong FENG
;
Yixiong ZHANG
;
Minying SONG
;
Xinsheng YAO
- Publication Type:Journal Article
- Keywords:
HLA-DR,DQ gene;
Association;
Epidemic hemorrhagic fever(EHF)
- From:
Chinese Journal of Immunology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between HLA-DR,DQ allele polymorphisms and onset of epidemic hemorrhagic fever(EHF)among Han Nationality in Zunyi area.Methods:Using group study,HLA-DR and DQ genotyping was conducted in 100 EHF cases and 100 controls among Han Nationality in Zunyi area with polymerase chain reaction-sequence specific primer(PCR-SSP),GF(gene frequency)and RR(relative risk)were calculated and compared.Results:The frequency of HLA-DRB1 16 in patients with EHF was higher than in the control group(RR=3.58,?2=4.916,P=0.0266
