Exploration of estradiol (E2) on the expression of aromatase of renal tissue in systemic lupus erythematosus (SLE) model mice
- VernacularTitle:雌二醇对系统性红斑狼疮小鼠模型肾组织芳香酶表达的影响
- Author:
Xiaoyun TANG
;
Baoling JU
;
Baohui SONG
;
Xia LI
;
Yunli JI
;
Changlong L
- Publication Type:Journal Article
- Keywords:
Estradiol;
Systemic lupus erythematosus lupus(SLE);
Aromatase
- From:
Chinese Journal of Immunology
2000;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of aromatase of renal tissue in systemic lupus erythematosus(SLE)model mice.Methods:BALB/c mice were induced SLE with homologuous splenic cell activated with ConA after being ovariectomized,and in the same time administered different doses of benzestrofol.E2 in peripheral blood and renal tissue was detected by ELISA and the expression of mRNA of aromatase in renal tissue was detected by RT-PCR in the 4th,6th,8th and 10th weeks.Results:The level of E2 of peripheral blood and renal tissue of SLE model mice became higher as benzestrofol exogenously administered heightened.Compared with control mice,the level of E2 in SLE model mice increased,and the expression of mRNA of aromatase of renal tissue increased with E2 increment.Conclusion:E2 promotes development of SLE through regulating expression of aromatase mRNA.
