The clinical significance of urine NTX,serum BAP in multiple myeloma
- VernacularTitle:尿NTX、血清BAP在多发性骨髓瘤的临床意义
- Author:
Aijun LIU
;
Wenming CHEN
;
Lihong LI
;
Jinwei LIU
- Publication Type:Journal Article
- Keywords:
multiple myeloma;
N-telopeptides of type Ⅰ collagen;
serum bone spesifi c alkaline phosphatase
- From:China Oncology
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:The role of urine N-telopeptides of type Ⅰ collagen(uNTX) and serum bone spesifi c alkaline phosphatase(sBAP)was confi rmed in osseous metastasis of solid tumors. The aim of this article was to study their role in multiple myeloma (MM). Methods:Thirty eight MM patients (22 new diagnosed, 12 relapsed or refractory, 4 plateau patients ) were examined. Ten age-matched healthy volunteers were used as controls. Urine and serum samples were taken from all patients and controls before therapy, after 3 months and 6 months chemotherapy. Urine samples of NTX, serum samples of BAP were measured with enzyme-linked immunosorbent assays (ELISA). Results:Urine NTX concentrations were signifi cantly higher in newly diagnosed and relapsed or refractory patients than that in plateau patients and controls. Serum BAP concentrations were signifi cantly lower than that in plateau patients and controls. In newly diagnosed patients, urine NTX values were signifi cantly higher in stage Ⅲ disease than in stage Ⅰ/Ⅱdisease, serum BAP values were signifi cantly higher in stage Ⅰ/Ⅱ disease than stage Ⅲ disease. At the third month, urine NTX were signifi cantly lower and serum BAP were signifi cantly higher as well as at the sixth month. But osteolytic lesions in X–ray had no change at the sixth month. Conclusions:Bone turnover markers uNTX, sBAP and bone destruction are closely interrelated in multiple myeloma, they change much earlier than X-ray. They are useful in monitoring progression and the therapeutic effect of myeloma.
