Erythromycin and alendronate inhibit aseptic loosening in murine osteolysis model
- VernacularTitle:红霉素和阿伦磷酸钠防治人工关节松动动物实验研究
- Author:
Kun TAO
;
Hao SHEN
;
Xianlong ZHANG
- Publication Type:Journal Article
- Keywords:
erythromycin;
alendronate;
air pouch;
animal model;
osteolysis;
aseptic loosening
- From:
Orthopedic Journal of China
2006;0(17):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To observe whether erythromycin and alendronate are effective in treating aseptic loosening in a murine osteolysis model. [Method]Air pouches were established in the back of BALB/c mice by injecting sterile air subcutaneously. After the air pouches were mature, grafts of calvaria from syngeneic mouse donors were implanted in the air pouches and polyethylene debris was injected into the air pouches. Mice were divided into 4 groups. In the first group, saline was injected into the air pouches.In the other three groups, polyethylene debris was used. Saline,erythromycin and alendronate were injected intraperitoneally separately.Pouch tissues were collected at 14 days after polyethylene debris administration for molecular and histologic analysis.[Result] Both erythromycin and alendronate inhibited osteoclastogenesis and bone resorption, but alendronate was not as effective as erythromycin in anti-inflammation.[Conclusion]Both erythromycin and alendronate can be promising drugs for the treatment of aseptic loosening.
