Effects of ephedrine on GFAP of astrocytes after cerebral ischemia-reperfusion injury in rats
- VernacularTitle:麻黄碱对脑缺血再灌注损伤大鼠脑内星形胶质细胞GFAP表达的影响
- Author:
Xiaoke ZHAO
;
Nong XIAO
;
Yue ZHANG
- Publication Type:Journal Article
- Keywords:
ephedrine;
cerebral ischemia-reperfusion;
astrocyte;
glial fibrillary acidic protein (GFAP);
rat
- From:Journal of Xi'an Jiaotong University(Medical Sciences)
1982;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of ephedrine on glial fibrillary acidic protein (GFAP) expression after cerebral ischemia-reperfusion injury in rats.Methods Altogether 60 male SD rats were randomly divided into sham-operation group,natural recovery group and ephedrine treatment group.The unilateral ischemia-reperfusion models were induced by clue-blocked method.The expression level of GFAP around ischemic area was examined by immunohistochemical technique at weeks 1,2,3 and 4 after operation.Results GFAP expression began to increase at 1 w and stabilized at 3 w in ephedrine treatment group and natural recovery group.There was a significant increase of GFAP expression in ephedrine treatment group compared with that in natural recovery group (P
