Correlation analysis of CXCL12,CXCR4 and VEGF-C expression and clinical significance in pancreatic cancer
- VernacularTitle:胰腺癌中CXCL12-CXCR4生物学轴与VEGF-C的表达及相关性研究
- Author:
Hongyu ZHANG
;
Liming FEI
;
Changliang WANG
;
Wenhua ZHAO
;
Bo ZHANG
;
Wuyuan ZHOU
;
Wensheng YU
;
Weixia ZHONG
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms?Stromal cell-derived factor 1?CXC chemokine receptor 4?Vascular endothelial growth factor-C
- From:
Chinese Journal of Current Advances in General Surgery
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of CXCL12-CXCR4 and VEGF-C in pancreatic cancer and relation to clinical pathology.Methods:The tissue samples including PAC,the cancerous peripheral tissues,the normal pancreatic tissues and peripheral lympho nodes were obtained from 30 patients with PAC.The expressions of CXCL12,CXCR4and VEGF-C proteins in these tissues were assayed by immunohistochemical staining.The expressions of CXCL12,CXCR4 and VEGF-C mRNA in PAC were also investigated by fluorescence quantitative real-time PCR.Results:In all the samples,the positive rates of CXCL12 protein in PAC,the cancerous peripheral tissues,the normal pancreatic tissues and peripheral lympho nodes were respectively 13.3%(4/30),46.7%(14/30),56.7%(17/30) and 50.0%(15/30).The positive rates of CXCR4 protein in PAC,the cancerous peripheral tissues,the normal pancreatic tissues and peripheral lympho nodes were respectively 80.0%(24/30),70.0%(21/30),26.7%(8/30) and 73.3%(22/30).The expression levels of CXCR4 mRNA in PAC tissues,the cancerous peripheral tissues and peripheral lympho nodes were higher than that in the normal pancreatic tissues(P
