THE EFFECTS OF LENTINAN ON THE PROLIFERATIVE RESPONSE OF MOUSE SPLEEN LYMPHOCYTES IN VITRO
- VernacularTitle:香菇多糖对体外小鼠淋巴细胞增殖反应的影响
- Author:
Ning DAN
;
Tanmu ZHANG
- Publication Type:Journal Article
- Keywords:
lentinan;
lymphocyte proliferation
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Lentinan could enhance the proliferative response of the mouse spleen lymphocytes to FHA, LPS ( Lipopolysaccharides ) and MLR ( Mixed Lymphocyte Reaction ) in vitro in a concentration-dependent manner. At the concentration of 25M-g/ml, it had the most prominent effects and the enhancing rates were 42.1%, 24.1% and 27.1% respectively. At much higher or lower concentrations, however, it had almost no effects. But lentinan at 25H-g/ml could inhibit the prolifera-tire response to Con A ( Concanavalin A ) and the inhibitory action increased with the increase in the concentration. At the concentration of 200 p-g/ml, the inhibition rate was 52.2%.
