Analysis on safety of combination therapy with amlodipine plus terazosin in middle aged and old male patients with essential hypertension
- VernacularTitle:氨氯地平联合特拉唑嗪治疗中老年男性原发性高血压的安全性分析
- Author:
Chen MAO
;
Tonghua ZANG
;
Xiping XU
- Publication Type:Journal Article
- Keywords:
Hypertension;
Antihypertensive agents;
Pharmacoepidemiology
- From:
Chinese Journal of Disease Control & Prevention
2008;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety of combination therapy with amlodipine and terazosin in middle aged and old male patients with essential hypertension.Methods Randomized,prospective,parallel study was carried out in middle aged and old male patients with essential hypertension in Anqing between August 2005 and February 2006.In this article,508 patients were chosen to appraise safety of the combination therapy.Results ①After 4 weeks,the heart rate of combination group changed from 68.9?7.7 to 67.7?6.9.There was no significant difference before and after treatment.②The combination group didn't affect the levels of blood glucose,lipid,electrolyte and the function of kidney and liver.③As regards tolerability,adverse experiences were observed in 4.1%,12.3%,and 13.2% of patients,respectively.Orthostatic hypertension did not happen in three groups during treatment.Conclusions The combination of amlodipine and Terazosin have no influence on the levels of blood glucose,lipid and the function of kidney and liver.Moreover,the combination was tolerated as well as its components.Through the adjustment of drug dosage,orthostatic hypotension did not happen in three groups during treatment.
