Immunological analysis of the swine vesicular disease virus (SVDV) recombinant P1 protein in Guinea pigs
- VernacularTitle:猪水疱病重组蛋白P1的豚鼠免疫试验
- Author:
Hong TIAN
;
Jinyan WU
;
Youjun SHANG
;
Haixue ZHENG
;
Shiqi SUN
;
Xiangtao LIU
;
Qingge XIE
- Publication Type:Journal Article
- Keywords:
Swine vesicular disease virus (SVDV);
Subunit vaccine;
Guinea pigs;
Immunized test
- From:
Chinese Journal of Immunology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the immunogeneicity of a subunit vaccine of capsid protein precursor(P1) of swine vesicular diseas(SVD).Methods:In this study,the guinea pigs were immunized with the home-made antigen,T-lymphocyte proliferation response,blocking ELISA and micro-neutralization assay were used to detect the effect of the immunized responses in guinea pigs.Results:The results indicated that a retroviral-based vaccine carrying the capsid protein precursor(P1) of SVD was able to elicit strong SVDV-specific humoral immune responses in guinea pigs.Conclusion:It encourages further work towards the development of a vaccine against SVDV infection.
