Study of specific immune response on mice induced by a DNA vaccine co-expressing both MAGE-1 and interleukin-18
- VernacularTitle:MAGE-1与IL-18共表达DNA疫苗在小鼠体内诱导特异性免疫应答能力的研究
- Author:
Guangmin YANG
;
Yang SHI
;
Yan TAN
;
Shouqing LI
;
Yinfu MA
- Publication Type:Journal Article
- Keywords:
MAGE-1;
IL-18;
Co-expressing DNA vaccine;
Immune response
- From:
Chinese Journal of Immunology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observate immunologic response of immunized mice by the vaccine pcIL-18-MAGE.Methods:Abundant plasmids were extracted and immunized mice,two booster injection were carried out at ten days intervals.Seven days after the third immunization,serum antibody against MAGE-1 and T cell subgroup were detected by FCM,and CTL killing activity were assayed through MTT.Results:About serum antibody against MAGE-1 and T cell subgroup,recombinant plasmids groups were all higher than the vacant plasmid pcDNA3 group(P
