The analysis for allelic polymorphism of HLA-A,B and DRB1 in Han race population in Xining region of China
- VernacularTitle:西宁地区汉族人群HLA-A、B和DRB1等位基因多态性分析
- Author:
Haixia CAO
- Publication Type:Journal Article
- Keywords:
Human leukocyte antigen A,B,DRB1;
Allele;
Polymorphism
- From:
Chinese Journal of Immunology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the HLA-A,B,DRB1 allele polymorphism of the Han race population in Xining region of China.Methods:Polymerase chain reaction and sequence-specific olignucleotide probe hybridizations were used to detect HLA-A,B and DRB1 alleles in 73 unrelated heath Han individuals from Xining region,and the results were compared with those of Han populations in China.Results:Eleven of alleles were detected and identified for HLA-A,Twenty for HLA-B,and seventeen for HLA-DRB.HLA-A02,A11,A30,A33;HLA-B13,B15,B37,B40,B46,B58;HLA-DRB103,DRB104,DRB109,DRB112,DRB113,DRB3,DRB4 were the most common alleles.Conclusion:The allelic polymorphism of HLA loci of Han race population in Xining area has owns characteristics.
