Changes of ultrastructures and respiratory function of the spinal cord mitochondrial in experimental spinal cord injury
- VernacularTitle:脊髓损伤后线粒体超微结构和呼吸功能的变化
- Author:
Weihua CAI
;
Ning ZHANG
;
Lianshun JIA
- Publication Type:Journal Article
- Keywords:
spinal cord injury;
mitochondria;
ultrastructure
- From:
Orthopedic Journal of China
2006;0(14):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To study changes of ultrastructures and respiratory function of the spinal cord mitochondrial in experimental spinal cord injury.[Method]Forty-eight SCI models in adult SD rats were built based on modified Allen's method.Mitochondria was extracted from injuried spinal cord tissue by using modified Estabrook's method at 6h,12h and 24h after SCI.Then ultrastructural changes and respiratory function,including R3,R4,RCR,P/O were observed.[Result]Ultrastructure of mitochondria was damaged greatly.The results revealed that R3、RCR and P/O of injuried spinal cord mitochondria decreased significantly after injury compared to the normal control group(P
