Intratumor Injection of Gene-Immunotherapy Combined with Hyperthermia Treatment for Lung Carcinoma
- VernacularTitle:基因及免疫制剂瘤内注射并射频容式加热治疗肺癌
- Author:
Yuan ZHANG
;
Jiaping ZHENG
;
Yihong CHEN
- Publication Type:Journal Article
- Keywords:
lung;
pulmonary carcinoma;
interventional radiology;
gene therapy;
hyperthermia;
tomography,X-ray computed
- From:
Journal of Practical Radiology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the feasibility and efficacy of percutaneous intratumor injection of gene-immunotherapy combined with capacitive radio-frequency hyperthermia treatment for advanced lung carcinoma under CT guided.Methods Thirty-one unresectable peripheric lung carcinomas(29 men and 2 women,10 squamous carcinomas,15 denocarcinoma and 6 alveolus carcinomas) in clinical Ⅲ~Ⅳ stage were undergone percutaneous intrastumor injection of H101 and ⅠL~Ⅱ under CT guided,and repeated at 8,29,35,57 and 64 d respectively as one course.During interventional therapy,radio-frequency hyperthermia carried out twice one week,totally 12 times per-patient.After one course 4 weeks later,the blood TSGF levels and CT changes of the tumors were observed.Results The short period effect included:CR in 0 case,PR in 22 cases,NC in 6 cases and PD in 3 cases,the total short-term efficacy rate was 71 percent(22/31).Significant statistical difference was found in the positive rate and quantitative level of the blood TSGF after on cycle(P
