Expression of MMP-2 in Rabbit VX_2 Hepatic Tumor Model
- VernacularTitle:兔VX_2肝癌模型的MMP-2的表达
- Author:
Xuming BAI
;
Bin WANG
;
Guiwen CAO
;
Yong JIN
- Publication Type:Journal Article
- Keywords:
liver;
neoplasm;
animal model;
rabbit;
matrix metalloproteinase-2
- From:
Journal of Practical Radiology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of matrix metalloproteinase-2(MMP-2) in the VX2 hepatic tumor.Methods 30 New Zealand white rabbit VX2 liver carcinoma models(all the tumors were verified by histopathology)were set up.The expressions of MMP-2 in 30 cases of VX2 tumor tissues and their pericarcinomatous tissues and normal hepatic tissues in 20 cases were detected by immunohistochemical staining with SP method at 2.5 weeks after implantation.The cell number of MMP-2 positive expression was counted by immunohistochemical stain.Results According to immunohistochemical results,the positiveness of MMP-2 was 86.7%(26/30) in tumor tissues and 53.3%(16/30) in pericarcinomatous tissues and no expressions of MMP-2 in normal hepatic tissues.The expression of MMP-2 were mainly in the tumor cytoplasm and intercellular substance,and also in the part of the tumor thrombi,the bile vessel epithelial cell and vascular endothelial cell.Conclusion The features of the expression of MMP-2 are similar to that of human HCC,and this model is a real animal model for clinical MMP-2 study of human HCC.
