The research for the expression of cyclooxyenase-2 (COX-2) and survivin in HCC tissues and their relationship
- VernacularTitle:COX-2、Survivin蛋白在原发性肝细胞癌(HCC)中表达及其相关性研究
- Author:
Yanqiu FANG
;
Yaling QI
;
Shaoqian SUN
;
Yan TAN
- Publication Type:Journal Article
- Keywords:
Hepatic cell carcinoma;
Cyclooxygenase-2;
Survivin;
Flow cytometry;
Immunohistochemistry
- From:
Chinese Journal of Immunology
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of COX-2 and Survivin in HCC tissues and their relationship for supplying experimental evidence for gene diagnosis and treatment of HCC.Methods:The expression of COX-2 and Survivin was detected in 30 cases of hepatocellular carcinoma and 10 normal liver tissue by Flow cytometry (FCM) and immunohistochemistry (SP).Results:Two experimental methods showed that the positive expression of COX-2 and Survivin in HCC was significanly higher than that in normal liver tissue and there was significanly positive correlation between the expression of COX-2 and Survivin.Conclusion:The hyper-expression of COX-2 and Survivin in tissue can reflex the biological behavior of HCC and there are synergistic effect between them during the development of HCC.A possible mechanism is inhibition of tumor cell apoptosis through upregulating Survivin by COX-2,and promoting abnormal cell proliferation in development of hepatocellular carcinoma.
