Efficacy of deproteinised cancellous bone combined with BMP and fibrin in healing of rabbit segmental radial defect
- VernacularTitle:异体脱蛋白松质骨复合纤维蛋白BMP修复兔桡骨缺损
- Author:
Gang DENG
;
Xingyan LIU
;
Keming CHEN
- Publication Type:Journal Article
- Keywords:
deproteinised cancellous bone;
fibrin;
bone morphogenetic protein(BMP);
tissue engineering;
bone defect;
repair
- From:
Orthopedic Journal of China
2006;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To repair segmental bone defect with the composite of deproteinised cancellous bone,bone morphogenetic protein(BMP) and fibrin.[Method] Bone defects were created in 36 New Zealand rabbits on the bilateral radii and treated with three kinds of implantations:A,composite of deproteinised cancellous bone,BMP and fibrin;B,of deproteinised cancellous bone;C,blank control.The defects were observed by entgenography,optical microscopy,and electron-microscopy at 2,4,8,12,16 weeks.[Result] The defects treated with A implantation regenerated much more new bone and bridged earlier than the defects treated with B implantation and got completely repaired 16 weeks after operation.The defects with B and C implantation couldn't get osseous tissue healing.[Conclusion]The composite of deproteinised cancellous bone,bone morphogenetic protein(BMP) and fibrin can be effectively used to repair segmental bone defect.
