Protective effect of Astragalus hoangtchy preconditioning on myocardial mitochondria in ischemia reperfusion injury in rabbits
- VernacularTitle:黄芪预处理对家兔心肌缺血再灌注后心肌线粒体结构及功能的影响
- Author:
Xiaoyan WANG
;
Guixia JING
- Publication Type:Journal Article
- Keywords:
Astragalus hoangtchy;
preconditioning;
myocardium;
ischemia-reperfusion injury;
mitochondrion
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the protective effect of Astragalus hoangtchy preconditioning on myocardial ischemia reperfusion injury in rabbits and structural and functional changes of mitochondria so as to provide prevention evidence of Astragalus hoangtchy being taken into clinical treatment for myocardial ischemia reperfusion injury.Methods Thirty-two healthy male rabbits were divided randomly into four groups: sham-operation group(Group A),ischemic reperfusion group(Group B),astragalus hoangtchy preconditioning group(Group C) and 5-HD plus Astragalus hoangtchy preconditioning group(Group D),with eight rabbits in each.All rabbits in the four groups were killed 2h after reperfusion.We examined Ca2+ concentration,MDA content,and SOD activity of myocardial mitochondria and observed ultrastructural changes of myocardium under electron microscope.Results SOD activity of myocardial mitochondria in Group C was significantly higher than that in Group B(P
