Chromatographic study on bio-affinity of drugs to rat aorta tissue and cultured smooth muscle cell in cell membrane
- VernacularTitle:药物在大鼠主动脉组织及其培养细胞的细胞膜色谱研究
- Author:
Dian ZHANG
;
Bingxiang YUAN
;
Xiuling DENG
;
Guangde YANG
;
Langchong HE
- Publication Type:Journal Article
- Keywords:
cell membrane;
chromatography;
?-adrenergic receptor
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the specificities of the cell membrane stationary phases(CMSP) with cell membrane chromatography(CMC).Methods Cell chromatographic columns were constructed for both rat aorta tissue cells and cultured rat aorta smooth muscle cells.Then the chromatographic affinities of ten ligands of ?-adrenergic receptor(?-AR) with both said chromatographic columns were investigated.Capacity factors(k'),as a chromatographic parameter,were calculated.Results The correlation analysis showed a positive correlation between the rat aorta tissue CMSP and the cultured rat aorta smooth muscle cell CMSP,with correlation factor of r=0.923,P
