THE ROLE OF OXYGEN RADICALS IN RAT ACUTE LUNG INJURY INDUCED BY PHORBOL MYRISTATE ACETATE
- VernacularTitle:氧自由基在PMA致大鼠急性肺损伤中的作用
- Author:
Li LI
- Publication Type:Journal Article
- Keywords:
acute lung injury;
lipid-peroxide;
DNA strand-break damage;
adult respiratory distress syndrome;
phorbol myristate acetate
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
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Abstract:
We tried to clarify the role of oxygen radicals [released from granulocytes stimulated by phorbol myristate acetate (PMA) in rat acute lung injury. It was found that DNA strand-break damage (DSBD) in peripheral white blood cells was significantly increased 40 min after injection of PMA. DSBD in lung tissue of rats treated with PMA was also markedly increased. The PMA-treated rats showed significantly higher lipid-peroxide (LPO) level in plasma and lung hemogenate than the controls. These results suggest that determination of DSBD, a simple and sensitive indicator for oxygen radical damaging, might be useful in the diagnosis of adult respiratory distress syndrome, when it is used together with measurement of plasma LPO.
