Research on genetic polymorphisms of HLA-DRB1 and DQB1 in the Hans of Zunyi
- VernacularTitle:遵义地区汉族HLA-DRB1、DQB1等位基因多态性的研究
- Author:
Junmin LUO
;
Wanbang SUN
;
Xuegui HUANG
;
Jihong FENG
;
Yixiong ZHANG
;
Xinsheng YAO
;
Mingying SONG
- Publication Type:Journal Article
- Keywords:
Zunyi;
HLA-DRB1,DQB1;
Allele frequency;
Polymorphism;
Polymerase chain reaction-sequence specific primer(PCR-SSP)
- From:
Chinese Journal of Immunology
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate frequencies and polymorphism of HLA-DRB1 and DQB1 allele in the Hans of Zunyi area.Methods:Polymerase chain reaction-sequence specific primers(PCR-SSP) were used to type HLA-DRB1 and DQB1 genes of 200 unrelated healthy Han individuals in Zunyi area.Results:13 HLA-DRB1 and 7 HLA-DQB1 alleles were obtained at low resolution level in all subjects.The allele DRB1*09,DRB1*08 and DQB1*05 were showed high distributing frequencies;The allele DRB1*10 and DQB1*04 were scarcely found with low distributing frequencies.Comparied with Northern and Southern Han people,it would seem that Han people in Zunyi are more closely related to the Southern ones.The allele B*07 was scarcely found in the Southern Han with a high distributing frequency(GF=2.0%).Conclusion:HLA-DRB1 and DQB1 of Han people in Zunyi have plenty of polymorphisms.They seem to distribute in line with the Southern Han's characteristics but have their own territory feature with a high B*07 frequency.
