Multi-slice CT Perfusion Study on Angiogenesis in Hepatocellular Carcinoma Induced by Hypoxia Inducible Factor-1?
- VernacularTitle:HIF-1?介导肝癌血管生成的多层CT灌注研究
- Author:
Yunchuan XIE
;
Xiangping ZHOU
- Publication Type:Journal Article
- Keywords:
carcinoma,hepatocellular;
tomography,X-ray computed;
hypoxia inducible factor-1?
- From:
Journal of Practical Radiology
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between multi-slice CT perfusion imaging and angiogenesis in hepatocellular carcinoma(HCC) induced by hypoxia inducible factor-1?(HIF-1?).Methods Multi-slice CT perfusion data were obtained in 34 cases of HCC and 11 cases of hepatic hemangioma identified by operation and pathology.Positive expression of HIF-1? and vascular endothelial growth factor(VEGF) protein of the lesions in all cases and surrounding normal hepatic tissue were investigated with SP immunohistochemistry.Microvessel density(MVD) was determined by anti-CD34 immunostaining.The correlation between multi-slice CT perfusion data and positive expression of HIF-1?,VEGF and CD34 was investigated simultaneously.Results Hepatic arterial perfusion(HAP) and hepatic arterial perfusion index(HAI) in HCC were higher than that of hepatic hemangioma and surrounding normal hepatic tissue(P
