Relationship of expression of CDX2 and PTEN proteins and gastric metaplasia
- VernacularTitle:CDX2和PTEN蛋白表达与胃黏膜肠上皮化生关系的临床研究
- Author:
Zhumei ZHAO
;
Jianping ZHANG
;
Fengjun LIU
;
Jingyan YANG
;
Wenjun LIU
;
Yan WANG
- Publication Type:Journal Article
- Keywords:
Intestinal metaplasia;
CDX2;
PTEN;
Stomach neoplasms
- From:
Chinese Journal of Current Advances in General Surgery
1999;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the relationship of expression of CDX2 and PTEN proteins and gastric metaplasia. Methods: Immunohistochemistry Envision method was used to detect the expression of CDX2 and PTEN proteins in simple intestinal metaplasia (SIM), atypical intestinal metaplasia (AIM) and gastric adenocarcinoma. Results: The positive rates of CDX2 in SIM, AIM and gastric adenocarcinoma was 82.6%, 51.5% and 36.4% respectively. The expression of CDX2 in gastric adenocarcinoma was significantly lower than that in SIM(P0.05). The positive rates of PTEN in SIM, AIM and gastric adenocarcinoma were 86.9%,75.8%and 47.7% respectively and the difference between SIM and gastric adenocarcinoma was significant (P
