Effect of ?-aminobutyric acid on proliferation of cytokine-induced killer cells
- VernacularTitle:?-氨基丁酸对人细胞因子诱导的杀伤细胞增殖的影响
- Author:
Jianqun CHEN
;
Nana TANG
;
Sujuan FEI
;
Junquan LIU
;
Fuxing CHEN
- Publication Type:Journal Article
- Keywords:
?-aminobutyric acid;
Cytokine-induced killer cells;
T cell proliferation;
Immunophenotype
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of GABA and A receptor agonist THIP on proliferation and apoptosis of cytokine-induced killer (CIK) cells.Methods:CIK cells were cultured by routine method,and then treated with different concentrations of GABA and THIP.The proliferation of CIK cells were investigated by MTT assay.The apoptosis,cell cycle and immunophenotype were investigated by flow cytometry.Results:GABA could inhibit the proliferation of CIK cells in a dose-dependent manner and affect the distribution of cell cycle of CIK cells(P
