Characteristic expression of tumor necrosis factor receptor 1 in decidua tissue and serum of normal pregnancy and in spontaneous abortion mice
- VernacularTitle:正常妊娠与自然流产小鼠模型蜕膜组织和血清中TNFR1的表达
- Author:
Junying YANG
;
Yaying MI
- Publication Type:Journal Article
- Keywords:
Decidua tissue;
Tumor necrosis factor receptor 1 (TNFR1);
Soluble tumor necrosis factor receptor 1(sTNFR1)
- From:
Chinese Journal of Immunology
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Comparing the expression of tumor necrosis factor receptor 1 (TNFR1) in decidua tissue and soluble tumor necrosis factor receptor 1(sTNFR1) in serum of normal pregnancy and spontaneous abortion mice to probe the relationship between TNFR1 and unexplained spontaneous abortion.Methods:The abortion-prone CBA?DBA/2 mating was established as the model of spontaneous abortion and nonabortion-prone CBA?BALB/c matings were used as the model of normal pregnancy.Immunohistochemistry method(SABC) was employed to detect the expression of TNFR1 in decidua tissue at the day 9 of gestation.The level of sTNFR1 in serum at the same time was determined by ABC-ELISA.Results:Compared with normal pregnancy model,the expression of TNFR1 in decidua tissue of spontaneous abortion was significantly increased (P
