Effect of Microcontent Formaldehyde Intake on the Serum p53 Antibody in S_(180) Tumour Mice
- VernacularTitle:低浓度甲醛摄入对S_(180)荷瘤鼠血清p53抗体的影响
- Author:
Zhanwen LIU
;
Pinkang WEI
;
Xiaofeng ZHANG
- Publication Type:Journal Article
- Keywords:
Formaldehyde;
Tumor;
p53 antibody
- From:
Journal of Environment and Health
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of formaldehyde exposure on the progress of explanted S180 tumour and the serum p53 antibody in mice. Methods 30 male SPF Kunming mice aged 6 weeks were randomly divided into control group,tumour group and formaldehyde group which drunk purified water,purified water contained 0.05% formaldehyde respectively. One week later S180 tumour cells (2?106) were implanted subcutaneously in the left fore armpit in tumour and formaldehyde group mice. The general state (weight,activity and spirit state),the appearing time and progress of solid tumour was recorded. Four weeks later the animal were sacrificed,the weight and volume of the tumour were measured,the serum p53 antibody was examined by ELISA. Results The activity and spirit state was normal in control group. In tumour and formaldehyde group the mice had withered hair and cachexia,such as emaciated,tired,retardation. In formaldehyde group the weight increase was slow in the first and second week,however it was rapid in 3 and 4 week,the appearing time of solid tumour was advanced,the weight,volume of the tumour were higher than those in tumour group(P
