Physiologically Based Pharmacokinetic Models for Use in Risk Assessment of Xylene
- VernacularTitle:生理药物代谢动力学模型及其在二甲苯危险度评价中的应用
- Author:
Chengxiang XIONG
- Publication Type:Journal Article
- Keywords:
Physiologically based pharmacokinetic model;
Risk assessment;
Xylene
- From:
Journal of Environment and Health
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
As a mature tool for estimating tissue dosimetry,physiologically based pharmacokinetic (PBPK) models are being used to simulate the process from an external chemical exposure to an internal exposure at a target site,for supporting quantitative predictions of risks to human health. This paper reviewed these models from three aspects: the general steps of model construction,the criteria of model evaluation,the use of model in risk assessment and taking xylene as an example particularly described the third aspect.
