In vivo biocompatibility of beta titanium alloys for internal fixation instruments
- VernacularTitle:钛铌锆?钛合金低弹性模量内固定材料的生物相容性研究
- Author:
Qingwei JIA
;
Congqin NING
;
Dongyan DING
- Publication Type:Journal Article
- Keywords:
internal fixaion;
titanium-niobium-zirconium;
biocompatible materials;
in vivo
- From:
Orthopedic Journal of China
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To develop new beta titanium alloys made of titanium, niobium and zirconium (Ti-Nb-Zr) which have higher strength, lower moduli of elasticity. Its biocompatibility in vivo is evaluated in this paper. [Method](1) 24 SD rats were used in the modified air pouch model experiments. Air was injected subcutaneously on the back of rats to form the pouches and the Ti-Nb-Zr particles were introduced into them. The liquid in the pouches was harvested 48 hours later for IL-6 and TNF-?ELISA procedure and the capsules for histology examination. All the results were compared with Ti-6Al-4V. (2) Ti-Nb-Zr bone plates were fixed onto tibias of rabbits. The capsules around the plates and the bone under them were observed at 4, 8, 12, 24 and 36 weeks respectively. Ti-Nb-Zr-bone interfaces were emphasized in this procedure. This time the control material was stainless steel. [Result](1)Ti-Nb-Zr and Ti-6Al-4V particles made the air pouches secret more TNF-? than that of the control (P
