Research Advancement of Hepatic Ischemic Preconditioning
- VernacularTitle:肝脏缺血预处理的研究进展
- Author:
Bogen YE
;
Xiaoping GENG
- Publication Type:Journal Article
- Keywords:
Ischemic preconditioning Hepatectomy Liver transplantation Ischemia-reperfusion injury
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize recent researches on mechanism of the hepatic ischemic preconditioning(IPC) and its clinical applications on hepatectomy and liver transplantation.Methods Relevant references about basic and clinical researches of hepatic IPC were collected and reviewed.Results Recent experimental researches indicated that IPC could relieve hepatic ischemia-reperfusion injury(IRI) by remaining and improving energy metabolism of liver,regulating microcirculation disorder,decreasing the production of lipid peroxidation and oxyradical.It could also inhibit the activation of inflammatory cells and the release of cytokine,suppress cell apoptosis and induce the release of endogenous protective substance.Till now,most of the clinical researches had confirmed the protective function of hepatic IPC,but there were still some references with opposite opinions.Conclusion Hepatic IPC could relieve liver IRI,but its clinical application value on hepatectomy and liver transplantation still need more researches to prove.
