Protective Effect of Peroxisome Proliferator-Activated Receptor ? Activator 15-Deoxyprostaglandin J_2 in Rat Hepatic Ischemia-Reperfusion Injury and Its Mechanism
- VernacularTitle:PPAR?激动剂15d-PGJ_2在大鼠肝脏缺血-再灌注损伤中的保护作用及机理
- Author:
Xiaofei CAO
;
Feng ZHANG
;
Wei ZHANG
;
Yewei ZHANG
- Publication Type:Journal Article
- Keywords:
Peroxisome proliferator-activated receptor ? 15-deoxyprostaglandin J2 Liver ischemia-reperfusion injury Nuclear factor-?B
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effect of peroxisome proliferator-activated receptor ?(PPAR?) activator 15-deoxyprostaglandin J2(15d-PGJ2) in rat hepatic ischemia-reperfusion injury and its mechanism.Methods The models of 70% warm ischemia-reperfusion injury were established in SD rats,rats were randomly divided into 4 groups: sham operation group,ischemia-reperfusion group,15d-PGJ2 group and 15d-PGJ2+GW9662 group.After reperfusion,serum AST and ALT levels were determined;the liver tissues were removed for measurement of activity of NF-?B and myeloperoxidase(MPO),TNF-? content and expression of ICAM-1.Results Compared with sham operation group,the serum levels of ALT and AST,and the activities of MPO and NF-?B,TNF-? content and expression of ICAM-1 in ischemia-reperfusion group,15d-PGJ2 group and 15d-PGJ2+GW9662 group were greatly improved(P
