Effects of wogonin on LPS-induced production of proinflammatory cytokines
- VernacularTitle:汉黄芩素对脂多糖诱导的促炎性因子的影响
- Author:
Huazi PIAO
;
Hong CUI
;
Rilong PIAO
;
Yingjun LI
- Publication Type:Journal Article
- Keywords:
wogonin;
microglia;
lipopolysaccharide(LPS);
nitric oxide(NO);
tumor necrosis facter-alpha(TNF-?);
interleukin-6(IL-6)
- From:
Journal of Xi'an Jiaotong University(Medical Sciences)
1981;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of wogonin on lipopolysaccharide(LPS-induced) proinflammatory cytokine production in activated microglia.Methods By using LPS-induced microglia activation model,nitric oxide(NO),tumor necrosis factor-alpha(TNF-?) and interleukin-6(IL-6) secreted by extracellular fluid were measured by ELISA.Results Microglia markedly produced NO,TNF-? and IL-6 in response to LPS.Wogonin,administered at 20-30 ?mol/L,significantly reduced the production of NO,TNF-? and IL-6 in microglia.Conclusion Wogonin has an inhibitory effect on the production of proinflammatory cytokines.
